Molecular basis of learning and memory
DOI:
https://doi.org/10.37609/srinmed.8Keywords:
Non-Associative Learning, Associative Learning, Memory, Long Term Potentiation, Synaptic PlasticityAbstract
As commonly known, learning is the process of acquiring a new information and memory is preservation of acquired information for later use. The difference in learning and memory capacities between different species and between different individuals of same species directed scientists to research the causes of this. According to commonly accepted approach these differences are due to the distinctions in synaptic alterations. In collaboration with advancing molecular techniques, the formation mechanisms of synaptic alterations, the reasons of differences between them, the changes that occur in neurons during learning and the changes that occur in neurons as a result of memory became popular research subjects nowadays. The researches that has been done are insufficient, however, many important findings are obtained until now. The changes that occur in pre-synaptic and post-synaptic neurons during simple non-associative learning, associative learning, short term memory and long term memory have been researched and different molecular mechanisms have been suggested.
References
Hebb DO. The organization of behavior; a neuropsychological theory. New York,: Wiley; 1949. xix, 335 p. p.
Mansvelder HD, Verhoog MB, Goriounova NA. Synaptic plasticity in human cortical circuits: cellular mechanisms of learning and memory in the human brain? Curr Opin Neurobiol. 2019;54:186-93. https://doi.org/10.1016/j.conb.2018.06.013
Kandel ER, Schwartz JH. Molecular biology of learning: modulation of transmitter release. Science. 1982;218(4571):433-43. https://doi.org/10.1126/science.6289442
Carew TJ, Walters ET, Kandel ER. Associative learning in Aplysia: cellular correlates supporting a conditioned fear hypothesis. Science. 1981;211(4481):501-4. https://doi.org/10.1126/science.7455692
Moroz LL. Aplysia. Curr Biol. 2011;21(2):R60-1. https:// doi.org/10.1016/j.cub.2010.11.028
Seel NM. Encyclopedia of the sciences of learning. New York: Springer; 2012.
Cevik MO. Habituation, sensitization, and Pavlovian conditioning. Front Integr Neurosci. 2014;8:13. https://doi.org/10.3389/fnint.2014.00013
Zuo F, Panda P, Kotiuga M, Li J, Kang M, Mazzoli C, et al. Habituation based synaptic plasticity and organismic learning in a quantum perovskite. Nat Commun. 2017;8(1):240. https://doi.org/10.1038/s41467-017-00248-6
Bear MF, Connors BW, Paradiso MA. Neuroscience : exploring the brain. Fourth edition. ed. Philadelphia: Wolters Kluwer; 2016. xlii, 975 pages p.
Purves D. Neuroscience. 4th ed. Sunderland, Mass.: Sinauer; 2008. xvii, 857, G-16, IC-7, I-29 p. p.
Byrne JH, Hawkins RD. Nonassociative learning in invertebrates. Cold Spring Harb Perspect Biol. 2015;7(5). https://doi.org/10.1101/cshperspect.a021675
Blumstein DT. Habituation and sensitization: new thoughts about old ideas. Animal Behaviour. 2016;120:255-62. https://doi.org/10.1016/j.anbehav.2016.05.012
Dash PK, Hochner B, Kandel ER. Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation. Nature. 1990;345(6277):718-21. https://doi.org/10.1038/345718a0
Kandel ER. The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB. Mol Brain. 2012;5:14. https://doi.org/10.1186/1756-6606-5-14
Kandel ER. The molecular biology of memory storage: a dialogue between genes and synapses. Science. 2001;294(5544):1030-8. https://doi.org/10.1126/science.1067020
Bear MF, Malenka RC. Synaptic plasticity: LTP and LTD. Curr Opin Neurobiol. 1994;4(3):389-99. https://doi.org/10.1016/0959-4388(94)90101-5
Shi SH, Hayashi Y, Petralia RS, Zaman SH, Wenthold RJ, Svoboda K, Malinow R. Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation. Science. 1999;284(5421):1811-6. https://doi.org/10.1126/science.284.5421.1811
Debanne D, Daoudal G, Sourdet V, Russier M. Brain plasticity and ion channels. J Physiol Paris. 2003;97(4-6):403-14. https://doi.org/10.1016/j.jphysparis.2004.01.004
Song I, Huganir RL. Regulation of AMPA receptors during synaptic plasticity. Trends Neurosci. 2002;25(11):578-88. https://doi.org/10.1016/s0166-2236(02)02270-1
Gundu C, Arruri VK, Yadav P, Navik U, Kumar A, Amalkar VS, et al. Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking. Cells. 2022;11(16). https://doi.org/10.3390/cells11162557
Hawkins RD, Kandel ER, Bailey CH. Molecular mechanisms of memory storage in Aplysia. Biol Bull. 2006;210(3):174-91. https://doi.org/10.2307/4134556
Mayford M, Kandel ER. Genetic approaches to memory storage. Trends Genet. 1999;15(11):463-70. https://doi.org/10.1016/s0168-9525(99)01846-6
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