A Evaluation Of The Frailty Index And Thiol-Disulphide Levels In Geriatric Orthopedic Injuries
Evaluation Of The Frailty Index
DOI:
https://doi.org/10.37609/srinmed.12Keywords:
Geriatric patient, orthopedic injury, oxidative stress, frailtyAbstract
Backround: One of the concepts recently discussed about old age is frailty. Frailty was found to be important in determining weakness and indulgence in the elderly. Frail older people are more likely to fall and experience related orthopedic trauma. Free oxygen radicals are known to cause oxidative stress in trauma patients. The aim of this study is to report the levels of frailty and thiol disulphide homeostasis and related factors in patients with geriatric orthopedic injury who presented to the emergency department.Methods: This study included 82 patients aged 65 and over who were admitted to the Emergency Department of XXX City Hospital in 2020 due to orthopedic trauma, and 38 people who presented for other reasons in a control group. FRAIL Frailty scale was used to evaluate frailty. In samples from patients' venous blood, native thiol and total thiol were analyzed.Results: The average age of the patients was78.48 ±7.86(min: 65-max: 99). Of the patients, 30.8% were in the prefrail group and56.7% were in the frail group. In patient and control group comparisons, total thiol values in the patient group were significantly lower, and disulphide, ischemia-modified albumin, index 1 and index 2 values were significantly higher in the patient group compared with the control group. There were significantly more prefrail individuals(41.5%) among orthopedic trauma patients, and frail individuals (81.6%) in the control group. There was a significant weak negative correlation between body mass index and native thiol and total thiol values.Conclusion: Oxidative stress is increased in patients with geriatric orthopedic injuries.
References
Lopez PM, Fernandez-Ballesteros R, Zamarron MD, Lopez SR. Anthropometric, body composition and health determinants of active ageing: a gender approach. J Biosoc Sci. 2011;43(5):597-610. doi: 10.1017/S0021932011000228.
Kenessary A, Zhumadilov Z, Nurgozhin T, Kipling D, Yeoman M, Cox L, et al. Biomarkers, interventions and healthy ageing. N Biotechnol. 2013;30(4):373-7. doi: 10.1016/j.nbt.2012.11.018.
Mulatti C, Calia C, De Caro MF, Della Sala S. The cumulative semantic interference effect in normal and pathological ageing. Neuropsychologia.2014;65:125-30. doi: 10.1016/j.neuropsychologia.2014.10.007
Abizanda P, Romero L, Sanchez-Jurado PM, Martinez-Reig M, Alfonso-Silguero SA, Rodriguez-Manas L. Age, frailty, disability, institutionalization, multimorbidity or comorbidity. Which are the main targets in older adults? J Nutr Health Aging. 2014;18(6):622-7. doi: 10.1007/s12603-014-0033-3.
Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Cardiovascular Health Study Collaborative Research Group. Frailty in older adults:evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):146-157. doi: 10.1093/ gerona/56.3.m146.
Al Snih S, Graham JE, Ray LA, Samper-Ternent R, Markides KS, Ottenbacher KJ. Frailty and incidence of activities of daily living disability among older Mexican Americans. Journal of rehabilitation medicine: official journal of the UEMS European Board of Physical and Rehabilitation Medicine. 2009;41(11):892-897. DOI: 10.2340/16501977-0424
Klein BE, Klein R, Knudtson MD, Lee KE. Frailty, morbidity and survival. Arch Gerontol Geriatr.2005;41:141-149. DOI: 10.1016/j.archger.2005.01.002
Bilir N, Paksoy N. Değişen dünyada ve Türkiye’de yaşlılık kavramı. Kutsal YG (ed).Temel Geriatri. 1. baskı. Ankara: Güneş Tıp Kitabevleri. 2007:3-9.
Chang TT, Schecter WP. Injury in the elderly and endof-life decisions. Surg Clin North Am. 2007;87(1):229-45.DOI: 10.1016/j.suc.2006.09.010
Yorgancı K. Travma. In: Gökçe-Kutsal Y, ed. Temel Geriatri. Ankara: Güneş Tıp Kitabevleri; 2007:1335-9.
Mehmet A, Sarıca N, Computed tomography fındıngs ın gerıatrıc trauma patıents who admıtted to emergency room (servıce) turkish journal of geriatrics 2015;18(4):280-284
Sen CK, Packer L. Thiol homeostasis and supplements in physical exercise. The American Journal of Clinical Nutrition. 2000;72(2):653-69doi: 10.1093/ajcn/72.2.653S.
Jones DP, Liang Y. Measuring the poise of thiol/disulfide couples in vivo. Free Radical Biology and Medicine. 2009;47(10):1329-38.DOI: 10.1016/j.freeradbiomed. 2009.08.021
- Polat M, Ozcan O, Sahan L, Üstündag Y, Alisik M, Yilmaz N, Erel Ö. Changes in thiol-disulfide homeostasis of the body to surgical trauma in laparoscopic cholecystectomy patients. Journal of Laparoendoscopic&Advanced Surgical Techniques. 2016;26(12):992-6. DOI: 10.1089/lap.2016.0381
Chianeh YR, Prabhu K. Protein thiols as an indication of oxidative stress. Arsiv Kaynak Tarama Dergisi. 2014;23(3):443-56.
Çaylak E. Çocuklarda kurşun zehirlenmesi, oksidatif stres ve tiyol bileşiklerin antioksidan etkisi. Çocuk Dergisi. 2010;10(1):13-23
Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clinical Biochemistry. 2014;47(18):326-32. DOI: 10.1016/j.clinbiochem.2014.09.026
Circu ML, Aw TY. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radical Biology and Medicine. 2010;48(6):749-62. DOI: 10.1016/j.freeradbiomed. 2009.12.022
Yuksel M, Ates I, Kaplan M, Alışık M, Erel Ö, Saygılı F et al. The dynamic thiol/disulphide homeostasis in inflammatory bowel disease and its relation with disease activity and pathogenesis. International Journal of Colorectal Disease. 2016;31(6):1229-31. DOI: 10.1007/s00384-015-2439-8
- Muradi H, Begum B. A Yaşlılarda kırılganlığı ölçmeye yönelik FRAİL ölçeğinin Türkçe geçerlik ve güvenirlik çalışması 2017
Bar-Or E, Lau J, Winkler V. A novel assay for cobalt albumin binding and its potential as a marker for myocardial ischemia—a preliminary report, Journal of Emergency Medicine. 2000;19(4):311–315. DOI: 10.1016/s0736-4679(00)00255-9
Vanitallie TB. Frailty in the elderly: contributions of sarcopenia and visceral protein depletion. Metabolism. 2003;52:22-26.DOI: 10.1016/s0026-0495(03)00297-x
Bender JS, Meinberg EG. Fragility fracture programs: are they effective and what is the surgeon’s role?. Curr Osteoporos Rep. 2015;13(1):30-34.DOI: 10.1007/s11914-014-0251-y
Li G, Thabane L, Papaioannou A, Ioannidis G, Levine MA, Adachi JD. An overview of osteoporosis and frailty in the elderly. BMC Musculoskelet Disord. 2017;18(1):46.DOI: 10.1186/s12891-017-1403-x
Sheweita SA, Khoshhal KI. Calcium metabolism and oxidative stress in bone fractures: role of antioxidants. Curr Drug Metab. 2007;8(5):519-525. DOI: 10.2174/138920007780866852
Handoll HH, Sherrington C, Mak JC. Interventions for improving mobility after hip fracture surgery in adults. Cochrane Database Syst Rev. 2011;3: CD001704. DOI: 10.1002/14651858.CD001704.pub4
Magaziner J, Hawkes W, Hebel JR. Recovery from hip fracture in eight areas of function. J Gerontol A Biol Sci Med Sci. 2000;55(9):498–507. DOI: 10.1093/gerona/55.9.m498
Parker M, Johansen A. Hip fracture. BMJ. 2006;333(7557):27–30.DOI: 10.1136/bmj.333.7557.27
Ensrud KE. Epidemiology of fracture risk with advancing age. J Gerontol A Biol Sci Med Sci. 2013;68(10):1236–42. DOI: 10.1093/gerona/glt092
Auais MA, Eilayyan O, Mayo NE. Extended exercise rehabilitation after hip fracture improves patients’ physical function: a systematic review and metaanalysis. Phys Ther. 2012;92(11):1437–51. DOI: 10.2522/ptj.20110274
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